A construction of Frobenius manifolds with logarithmic poles and applications

A construction theorem for Frobenius manifolds with logarithmic poles is established. This is a generalization of a theorem of Hertling and Manin. As an application we prove a generalization of the reconstruction theorem of Kontsevich and Manin for projective smooth varieties with convergent Gromov-Witten potential. A second application is a construction of Frobenius manifolds out of a variation of polarized Hodge structures which degenerates along a normal crossing divisor when certain generation conditions are fulfilled.Comment: 46 page

The Value of Moderate Obsession: Insights from a New Model of Organizational Search

This study presents a new model of search on a “rugged landscape,” which employs modeling techniques from fractal geometry rather than the now-familiar NK modeling technique. In our simulations,firms search locally in a two-dimensional fitness landscape, choosing moves in a way that responds both to local payoff considerations and to a more global sense of opportunity represented by a firm-specific “preferred direction.” The latter concept provides a very simple device for introducing cognitive or motivational considerations into the formal account of search behavior, alongside payoff considerations. After describing the objectives and the structure of the model, we report a first experiment which explores how the ruggedness of the landscape affects the interplay of local payoff and cognitive considerations (preferred direction) in search. We show that an intermediate search strategy, combining the guidance of local search with a moderate level of non-local “obsession,” is distinctly advantageous in searching a rugged landscape. We also explore the effects of other considerations, including the objective validity of the preferred direction and the degree of dispersion of firm strategies. We conclude by noting available features of the model that are not exercised in this experiment. Given the inherent flexibility of the model, the range of questions that might potentially be explored is extremely large.Rugged Landscapes; Local Search; Cognition; Obsession; Fractal Geometry

A Core/Periphery Perspective on Individual Creative Performance: Social Networks and Cinematic Achievements in the Hollywood Film Industry

The paper advances a relational perspective to studying creativity at the individual level. Building on social network theory and techniques, we examine the role of social networks in shaping individuals’ ability to generate a creative outcome. More specifically, we argue that individuals who occupy an intermediate position between the core and the periphery of their social system are in a favorable position to achieve creative results. In addition, the benefits accrued through an individual’s intermediate core/periphery position can also be observed at the team level, when the same individual works in a team whose members come from both ends of the core/periphery continuum. We situate the analysis and test our hypotheses within the context of the Hollywood motion picture industry, which we trace over the period 1992–2003. The theoretical implications of the results are discussed

Entropy and Multi-Fractality for the Myeloma Multiple TET 2 gene

The nucleotide and amino-acid distributions are studied for two variants of mRNA of gene that codes for a protein which is involved in multiple myeloid. Some patches and symmetries are singled out, thus, showing some distinctions between the two variants. Fractal dimensions and entropy are discussed as well

Friends, Cliques and Gifts: Social Proximity and Recognition in Peer-Based Tournament Rituals

Two main accounts of the effect of proximity between candidates competing for recognition and members of the evaluating audience in the underlying social structure can be extrapolated from extant literature on peer-based tournament rituals and cultural fields. Following a Bourdieusian tradition, one account – which we label self-reproduction – insists on the catalyzing effect of social proximity in shaping recognition along relational lines. Drawing from recent scholarship on social evaluation, a second account – which we label intellectual distance – suggests that social proximity deters recognition. We probe the influence of different articulations of social proximity (i.e., direct ties, cliquishness and reciprocity) on recognition by studying awarding decisions within the context of the Norwegian advertising industry. Interviews with key informants and econometric results suggest that, while self-reproduction tends to prevail over intellectual distance, these effects co-exist and their relative influence varies across levels of recognition. We gauge the relative saliency of the two accounts by using a mix-method approach. Important implications for research on social evaluation and recognition in peer-based tournament rituals are drawn

New factors enhancing the reactivity of cysteines in molten globule-like structures

Protein cysteines often play crucial functional and structural roles, so they are emerging targets to design covalent thiol ligands that are able to modulate enzyme or protein functions. Some of these residues, especially those involved in enzyme mechanisms-including nucleophilic and reductive catalysis and thiol-disulfide exchange-display unusual hyper-reactivity; such a property is expected to result from a low pK(a)and from a great accessibility to a given reagent. New findings and previous evidence clearly indicate that pK(a)perturbations can only produce two-four-times increased reactivity at physiological pH values, far from the hundred and even thousand-times kinetic enhancements observed for some protein cysteines. The data from the molten globule-like structures of ribonuclease, lysozyme, bovine serum albumin and chymotrypsinogen identified new speeding agents, i.e., hydrophobic/electrostatic interactions and productive complex formations involving the protein and thiol reagent, which were able to confer exceptional reactivity to structural cysteines which were only intended to form disulfides. This study, for the first time, evaluates quantitatively the different contributions of pK(a)and other factors to the overall reactivity. These findings may help to clarify the mechanisms that allow a rapid disulfide formation during the oxidative folding of many proteins

The Social Structure of Consecration in Cultural Fields: The Influence of Status and Social Distance in Audience–Candidate Evaluative Processes

Building on sociological research that examines the allocation of rewards in peer evaluations, we argue that the recognition of cultural producers’ work varies with their status and social distance from the audience members who evaluate them. We study the influence of these two mechanisms within the context of the Norwegian advertising industry. Specifically, we looked at how cultural producers’ status and social distance from jury members affect their chances of being honored in “The Silver Tag” – one of the main digital advertising award contests in Norway – during the period 2003–2010. While our findings provide support for status-based rewards allocation, the positive effects of status may be more circumscribed than previously thought. When accounting for the existence of previous connections between audience members and cultural producers, we find that cultural producers are more or less likely to receive an accolade depending on their degree of separation from the audience members. By exposing network-based determinants of consecrating decisions, and suggesting that the positive effects of status may be more circumscribed than previously thought, our findings shed important light on the social foundations of evaluation and, more broadly, the mechanisms of reward allocation in cultural fields

Creativity in Social Networks: A Core-Periphery Perspectiv

Building on socio-structural explanations, this article elaborates on the tension between individual actors’ positions along the core-periphery continuum of the social field and their ability to gain legitimacy for their creative work. Peripheral actors are less constrained by the field’s normative pressures and free to experiment with un- conventional ideas and solutions, but they may struggle to mobilize attention and harness the symbolic and material resources needed to legitimate their work. By contrast, core players are more effective at leveraging networks to build consensus, but they often exhibit a propensity toward more incremental work due to their higher levels of assimilation into the conventions of the field. To resolve this tension this article advances a strategy which we term optimal network structuration strategy . This strategy implies forming ties that link the two ends of the core-periphery spectrum, in the attempt to increase the likelihood of generating novelty while also enhancing the ability to make such novelty manifest and visible to the field. The theoretical and managerial implications are discussed